CHORALIS nemzetközi tanulmány – 2024

Aim: Real-world evidence on the management of hemorrhoidal disease (HD) is limited. This international study collected clinical practice data on the effectiveness of conservative treatments for acute HD on symptoms and quality of life (QoL). Patients & methods: The 4-week observational prospective CHORALIS study involved adult outpatients. Results: Of 3592 participants, 3505 were analyzed. Pain and discomfort were the most common symptoms. Most treatments were venoactive drugs (VADs; 90.9%), particularly micronized purified flavonoid fraction (MPFF; 73.7%) and diosmin (14.6%). MPFF was associated with a significantly greater proportion of patients with no symptoms (48.8 vs diosmin 34.4%, p < 0.001).

Conclusion: In this prospective real-world study, conservative therapies consisting mainly of VADs, including MPFF, improved the clinical signs and symptoms of disease.

Plain language summary: Hemorrhoids can cause symptoms like pain, bleeding and swelling. This study looked at how well non-surgical treatments work. Most people were treated with venoactive drugs (mostly MPFF). The results showed that these treatments helped to improve symptoms and quality of life, and MPFF seemed to work better than diosmin. Overall, the results suggest that using treatments that include VADs, especially MPFF, can make a positive difference.